Prime
Prime is the name of the planet that the main Prime Defenders storyline is based in. The universe it is within is known to include many other worlds/planets, though very few have been touched upon. Prime is filled with advanced technology, sprawling cities and is inhabited by (aside from regular humans) many heroes and villains alike that possess supernatural/superhuman capabilities.
Notable Locations on Prime
Rockfall
Rockfall is an easy coast city in Prime and the main location setting for most of Season 1. It's bordered by both a desert and coastline.
Centurion High
Centurion High School is a public school in the city of Rockfall, of which the Prime Defenders attended in Season 1. It's named for the famed hero of the same name.
Harttawa Island
Also known as the Island of Amalgam, Harttawa Island is an island off the coast of Rockfall made up of mostly jungle. It is heavily wooded. The location was where the Prime Defenders would go for their very first mission as set by Ms. Gilbert, to rescue scientist Dr. Luts from a "secret" facility they believed was on the island. the grounds for human and animal genetic (and otherwise) experimentation. The scientific facility on the island, watched over at the start of the campaign by Wavelength, housed many "amalgamations" of humans and animals, animals and other animals, etc.
Amalgam Facility
The unnamed facility on Harttawa Island where various cross-species genetic (and otherwise) experimentation was taking place, and Dr. Luts was being kept by villains running said facility (under direction of Overlord) for her knowledge on the topic. It was located deep within the jungle there, and was effectively blown up by the Prime Defenders in Episode 4: Heroes Don't Run. The activity as the facility was previously monitored by Wavelength. Information collected from this very facility as well as Dr. Luts' general research was found to also have been illegally acquired by Bell Tech to develop a medication known as Respilin.
Supermax Prison
The maximum security prison located in the desert directly outside of Rockfall, and a sister location of the one in Freedom City. This prison is where Wavelength and Le'Frog were being kept initially at the start of S2. The building was entirely destroyed following the possession of Atlas by the Chaos Zone demons, allowing many inmates, including those two, to escape.
New Haven
New Haven is the largest city on Prime, is inhabited by a large number of famous superheroes, and is the a location setting for some of Season 2. It's an undisclosed number of miles away from Rockfall and is also located along the east coast.
Freedom City
Freedom City is an existing, canonical city within Mutants and Masterminds that DM Bizly uses with a number of modifications to the location. A similar map to the one shown on-screen in S2 Episode 14 can be found here, though said modifications should be noted -- thus this map is, likely, not entirely accurate to the actual Freedom City within Prime.
The city is a few territories away from New Haven -- approximately 800-1,000 miles out. As such, it's also along the east coast of Prime. Outside of the city is a large 6-lane highway. The Prime Defenders reach it in S2 Episode 11: New Lich In Town when they follow the Lich through the portal from Fauna back into Prime.
Supermax Prison
The maximum security prison located in Freedom City, and a sister location of the one in the Rockfall desert. It's said to have been standing as a facility for about a century, but has underwent many changes and renovations since (as evident by Ms. Gilbert's modifications). The interior is located within a pocket dimension made by Ms. Gilbert, as well. Many of the rooms inside the main prison area are individually numbered and look like hotel rooms from the outside, which Wordsmith notes is a touch also made by Ms. G because she thought it would make them feel more "homey".
WATCH HQ
One of the two headquarters of the hero organization WATCH (the other being in space) is located in Freedom City, near the docks (presumably the ones near City Center).
Deadwood
Deadwood is the hometown of William Wisp, very far away from the cities of which PD has generally taken place. It is known to have some kind of "monster" problem, as noted by William. There also seem to be many supernatural/paranormal occurrences there, of which William and previous friends of his often investigated.
Whispering Woods
Ambiguous Deadwood location mentioned to have been visited by William Wisp (WIP).
Spirit World
The Spirit World is a dimension within Prime presumably accessible through multiple methods, the known of which include dying or using the demonic book possessed by Ashe Winters.
Chaos Zone
tbd Location without "law", essentially, within the Spirit World. Outside of Mallard Conway's control, home to The Trickster and red spirits capable of possessing people and causing them to behave violently, erratically and unpredictably.
Hillwood
West coast city. TBD.
Base Locations
Prime Defenders HQ
The PDHQ is the previous, now destroyed, base of the Prime Defenders. It had the appearance of a run down abandoned warehouse. Much of the interior was underground. It is located in Rockfall.
Hall of Elements
The second, technical acting Prime Defenders base and previous home(?) to Tide and his brothers, Shockwave, Magma and Whirlwind. It is also located in New Haven (fact check).
Prime Defenders Winnebago
The actual current "base" of the Prime Defenders, of which they travel around in and sleep in. Purchased at Ben Dover Car Dealership in New Haven (fact check) by the group after winning money in a pit fight in S2 E3. Its exterior is primarily golden and blue. The words "Prime Defenders Landscaping" are scraped in on the side, with (Heroism) in tinier text below. There is a knife taped to the bumper. The RV has the ability to turn invisible, but only does so while parked.
Inside, it has the appearance of a relatively typical RV. There are 2 fuzzy wisps (instead of dice) hanging from the rear view mirror. The seats are dark purple, there are white tables and walls accented with red and blue stripes, and there are 3 stacked bunk beds in the back. There is also a brick oven pizza forge inside (it makes pizza). There is no bathroom; only a shimmering blue window that, when leapt through, creates a motorcycle for you (every time). Dakota's are red and black with white flame accenting and high handlebars. He wears a black leather DC jacket that reads "PD" on the back when on one. Vyncent's are a white and purple with golden accenting speed bike. William's are a traditional motorcycle with light blue and black coloring and an ethereal tint to it. He wears a leather biker jacket that turns into flames at the bottom when on one.
Locations outside of Prime
Fauna
Fauna is the home world of Vyncent Sol and Mynerva. It's more reminiscent of a D&D or typical fantasy world.
Flora
Flora is the hometown of Vyncent Sol and Mynerva. Little is known about the details of the location.
France
France is noted to be a separate planet by Bizly in the Just Rolled With it for S2 Episode 14. The state it is in is currently ambiguous.